Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant

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논문

Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant

학술지

ChemCatChem

저자명

Tseliou, Vasilis; Knaus, Tanja; Vilí m, Jan; Masman, Marcelo F.; Mutti, Francesco G.

초록

AbstractA NADH‐dependent engineered amine dehydrogenase from Geobacillus stearothermophilus (LE‐AmDH‐v1) was applied together with a NADH‐oxidase from Streptococcus mutans (NOx) for the kinetic resolution of pharmaceutically relevant racemic α‐chiral primary amines. The reaction conditions (e. g., pH, temperature, type of buffer) were optimised to yield S‐configured amines with up to >99 % ee.

발행연도

2020

발행기관

John Wiley and Sons Inc.

ISSN

1867-3880

ISSN

1867-3899

권

호

페이지

pp.2184-2188