BioChem - DOS

Continuous production and recovery of itaconic acid in a membrane bioreactor

Bioresource technology : biomass, bioenergy, biowastes, conversion technologies, biotransformations, production technologies

Carstensen, F.; Klement, T.; Buchs, J.; Melin, T.; Wessling, M.

This study presents the fermentative production of the platform chemical itaconic acid using the fungus Ustilago maydis. The innovative aspect here is that the fermentation is run continuously with integrated cell retention and product recovery using membranes. Unlike conventional membrane processes, we use the recently introduced ''reverse-flow diafiltration'' which prevents performance loss by periodically reversing the flow direction. Results show that filtration stability can be (1) significantly improved compared to conventional membrane processes and (2) product recovery was constantly high at highly dynamic conditions. This is especially remarkable when taking into account the complex nature of fungi cells which tend to block surfaces rapidly.

2013

Elsevier Applied Science

0960-8524

137

pp.179-187

10.1016/j.biortech.2013.03.044

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART65929540

Membrane reactor; Process intensification; Itaconic acid; Continuous fermentation; Submerged filtration