BioChem - DOS

A Successful Treatment Approach in 2 Patients With Type 1 Plasminogen Deficiency: Intratracheal Application of Fresh Frozen Plasma and Tissue Plasminogen Activator

Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology

Al, Serdar; Ulusoy, Oktay; Asilsoy, Suna; Uzuner, Nevin; Kangalli, Ozge; Atay, Ozge; Odaman Al, Isik; Ates, Oguz

<P>Background:<P>Respiratory system involvement is common in congenital plasminogen deficiency. Although many treatment approaches have been tried, there is still no definitive treatment for respiratory system involvement.</P></P><P>Observation(s):<P>We report 2 congenital plasminogen deficiency cases, who presented with severe respiratory symptoms, for whom a novel treatment modality was tried. After intravenous administration of FFP (fresh frozen plasma), tissue plasminogen activator and FFP were administered intratracheally, and respiratory system findings improved.</P></P><P>Conclusions:<P>Intratracheal administration of tissue plasminogen activator and FFP is an available treatment modality for patients with lung involvement. Fibrin plaques should be carefully removed and new lesion formation should be prevented.</P></P>

2023

Ovid Technologies (Wolters Kluwer) - Lippincott WilliamsWilkins

1077-4114

1536-3678

45

7

pp.423-426

10.1097/mph.0000000000002698

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART126621062