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When constants are no longer constant: The case of inhibition in bioprocesses

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논문

When constants are no longer constant: The case of inhibition in bioprocesses

학술지

Biochemical engineering journal

저자명

Segura, C.; Vergara, C.; Seeger, M.; Donoso-Bravo, A.; Jeison, D.

초록

Traditional models describing microorganisms growth assume that changes in the environmental conditions generate immediate responses in microbial population. However, reports are available indicating that in some cases this may not be the case. The existence of a delayed inhibition response (DIR) was studied, exposing a microalgae culture to inhibitory ammonia concentrations. Results revealed the existence of considerable delays in the microalgae response, even when imposing conditions promoting null microalgal activity. Even an extremely unfavourable condition such as 1500mgL<SUP>-1</SUP> of total ammonia nitrogen and pH 9 takes about 24h to induce complete inhibition. The existence of DIR may cause serious deviations between predictions given by traditional models and real behaviour of a culture. Inclusion of DIR in traditional models may be accomplished by assuming model parameters as variables depending on time. In other words, assuming that inhibition ''constant'' is no longer constant, but a function of exposure time.

발행연도

2017

발행기관

Elsevier

ISSN

1369-703x

123

페이지

pp.24-28

주제어

Delay; Inhibition; Modelling; Ammonia; Microalgae

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1 2023-12-11

논문; 2017-07-01

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