BioChem - DOS

Highly Efficient Synthesis of (R)-3-Quinuclidinol in a Space-Time Yield of 916 g L-1 d-1 Using a New Bacterial Reductase ArQR

Organic letters

Zhang, Wen-Xia; Xu, Guo-Chao; Huang, Lei; Pan, Jiang; Yu, Hui-Lei; Xu, Jian-He

<P>A new keto reductase (<I>Ar</I>QR), identified from <I>Agrobacterium radiobacter</I> ECU2556, can efficiently reduce 3-quinuclidinone in excellent enantioselectivity and high space&ndash;time yield for the synthesis of (<I>R</I>)-3-quinuclidinol, a chiral building block of many antimuscarinic agents. This is the first time that a high yield of (<I>R</I>)-3-quinuclidinol up to 916 g L<SUP>&ndash;1</SUP> d<SUP>&ndash;1</SUP> using a bioreduction approach is reported.</P><P><B>Graphic Abstract</B><BR><IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2013/orlef7.2013.15.issue-19/ol402269k/production/images/medium/ol-2013-02269k_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol402269k'>ACS Electronic Supporting Info</A></P>

2013

American Chemical Society

1523-7060

15

19

pp.4917-4919

10.1021/ol402269k

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