초록
<P>Cyanobacteria are oxygenic photoautotrophs that serve as potential platforms for the production of biochemicals from cheap and renewable raw materials – sunlight, water, and carbon dioxide. Systems level analysis of the metabolic network of these organisms could enable the successful engineering of these organisms for the enhanced production of target chemicals. Metabolic modeling techniques including both stoichiometric and kinetic modeling with a genome-wide coverage enable a global assessment of metabolic capabilities. Recent studies guided by such modeling techniques have engineered strains for the enhanced production of valuable chemicals such as ethanol, <I>n</I>-butanol, 1,3-propanediol, glycerol, limonene, and isoprene from CO<SUB>2</SUB>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Model-based strain designing has been demonstrated before in cyanobacteria. </LI> <LI> Both GSM and Kinetic models for cyanobacterial are available. </LI> <LI> Lack of comprehensive heterogenous ’omics datasets hinder kinetic model parameterization. </LI> <LI> Model-based strain designs have so far been demonstrated only in model cyanobacterial strains. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>