<P><B>Abstract</B></P> <P>In this study, a novel attempt has been made to generate energy-efficient biomethane from marine macroalgae (<I>Chaetomorpha antennina)</I> by coupling thermochemical liquefaction with a disperser (thermo-chemo disperser (TCD) liquefaction). A temperature of (80 °C), pH 11 and disperser g-force of 1613 g were considered optimal parameters for effective solubilization and energy-efficient methane generation. This combinative liquefaction considerably reduced the treatment time and specific energy from 60 to 15 min and 6294 to 800 kJ/kg TS. The highest volatile fatty acids (VFA) accumulation of 890 mg/L was recorded in TCD compared to a thermo disperser (TD) (750 mg/L) and disperser (D) (322 mg/L) during anaerobic fermentation. TCD enhances the methane production potential of macroalgal biomass and a higher methane production of 215 mL/g VS was achieved for TCD compared to TD (149 mL/g VS) and D samples (100 mL/g VS), respectively. Cost analysis confirmed the field applicability of TCD liquefaction with a net profit of 90 USD/ton of marine macroalgae. A high energy ratio of 1.5 was achieved with the proposed mode of pretreatment (TCD) compared to TD (0.95) and D (0.28) pretreatment. Therefore, <I>C. antennina</I> is considered a suitable feedstock for methane generation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thermo chemo disperser aided liquefaction enhance the disintegration efficiently. </LI> <LI> Combined pretreatment had achieved higher liquefaction at 800 kJ/kg TS of energy. </LI> <LI> Kinetic analysis explains that rate was improved in combined pretreatment. </LI> <LI> Energy ratio of about 1.5 was achieved in thermo chemo disperser pretreatment. </LI> </UL> </P>