초록
<P><B>Abstract</B></P><P>Dynamic reductive kinetic resolutions of racemic 3‐arylalkanones have been performed by the proper combination of an alcohol dehydrogenase and a basic anionic resin. The best results were found for the bioreduction with the alcohol dehydrogenase type A from <I>Rhodococcus ruber</I> DSM 44541 overexpressed in <I>Escherichia coli</I> (<I>E. coli</I>/ADH‐A) and the commercially available evo‐1.1.200, while the Amberlite IRA‐440 C and the DOWEX‐MWA‐1 resins allowed efficient <I>in situ</I> racemizations. Reaction conditions were optimized in terms of enzyme source and loading, type and amount of resin, pH, temperature and reaction times, obtaining a series of (<I>R</I>,<I>R</I>)‐substituted propan‐2‐ols with good conversions and both diastereoselectivity and stereoselectivity. As a proof of concept, the subsequent intramolecular cyclization of a selected propan‐2‐ol substrate afforded a valuable isochroman heterocycle without any loss of the optical purity.</P>