초록
<P>An efficient and convenient platform for the facile synthesis of phosphorylated ketoses is described. All eight phosphorylated ketopentoses were produced using this platform starting from two common and inexpensive aldoses (<SMALL>d</SMALL>-xylose and <SMALL>l</SMALL>-arabinose) in more than 84% isolated yield (gram scale). In this method, reversible conversions (isomerization or epimerization) were accurately controlled toward the formation of desired ketose phosphates by targeted phosphorylation reactions catalyzed by substrate-specific kinases. The byproducts were selectively removed by silver nitrate precipitation avoiding the tedious and time-consuming separation of sugar phosphate from adenosine phosphates (ATP and ADP). Moreover, the described strategy can be expanded for the synthesis of other sugar phosphates.</P><P><B>Graphic Abstract</B><BR><IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/accacs/2016/accacs.2016.6.issue-3/acscatal.5b02234/production/images/medium/cs-2015-02234k_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cs5b02234'>ACS Electronic Supporting Info</A></P>