BioChem - DOS

Photosynthetic production of itaconic acid in Synechocystis sp. PCC6803

Journal of biotechnology

Chin, T.; Sano, M.; Takahashi, T.; Ohara, H.; Aso, Y.

Here, we report the photosynthetic production of itaconic acid (IA), a promising building block, from carbon dioxide (CO<SUB>2</SUB>) by Synechocystis sp. PCC6803. The engineered PCC6803 strain expressing cis-aconitate decarboxylase, the key enzyme in IA biosynthesis, produced 0.9mg/L and 14.5mg/L of IA at production rates of 42.8&mu;gL<SUP>-1</SUP>day<SUP>-1</SUP> and 919.0&mu;gL<SUP>-1</SUP>day<SUP>-1</SUP>, under conditions of constant bubbling with air and 5% CO<SUB>2</SUB>, respectively. This is the first report on the possibility of IA production from CO<SUB>2</SUB> via the photosynthetic process in cyanobacteria.

2015

Elsevier Science Publishers

publisher-specific-oa

0168-1656

1873-4863

195

pp.43-45

10.1016/j.jbiotec.2014.12.016

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART71338554

http://manuscript.elsevier.com/S0168165614010608/pdf/S0168165614010608.pdf

Itaconic acid; Synechocystis sp. PCC6803; Photosynthesis; cis-Aconitate decarboxylase