초록
<P>The biocatalytic oxidative tandem decarboxylation of C<SUB>7</SUB>–C<SUB>18</SUB> dicarboxylic acids to terminal C<SUB>5</SUB>–C<SUB>16</SUB> dienes was catalyzed by the P450 monooxygenase OleT with conversions up to 29 % for 1,11‐dodecadiene (0.49 g L<SUP>–1</SUP>). The sequential nature of the cascade was proven by the fact that decarboxylation of intermediate C<SUB>6</SUB>–C<SUB>11</SUB> ω‐alkenoic acids and heptanedioic acid exclusively gave nonconjugated 1,4‐pentadiene; scale‐up allowed the isolation of 1,15‐hexadecadiene and 1,11‐dodecadiene; the system represents a short and green route to terminal dienes from renewable dicarboxylic acids.</P>