Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

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논문

Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

학술지

RSC advances

저자명

Mathew, Sam; Deepankumar, Kanagavel; Shin, Giyoung; Hong, Eun Young; Kim, Byung-Gee; Chung, Taeowan; Yun, Hyungdon

초록

<P>A novel thermostable ω-transaminase from <I>Thermomicrobium roseum</I> which showed broad substrate specificity and high enantioselectivity was identified, expressed and biochemically characterized. The advantage of this enzyme to remove volatile inhibitory by-products was demonstrated by performing asymmetric synthesis and kinetic resolution at high temperature.</P>

발행연도

2016

발행기관

The Royal Society of Chemistry

ISSN

2046-2069

권

호

페이지

pp.69257-69260

DOI

10.1039/c6ra15110h