초록
<P>Amino acids hold significant importance in the diagnosis and treatment of various chronic diseases. Accurate solid-liquid equilibrium data are the key to drug synthesis and chemical production. However, the studies on the solid-liquid equilibrium of amino acids remain limited. In this work, the solid-liquid equilibrium of the <SMALL>L</SMALL>-tryptophan + <SMALL>L</SMALL>-phenylalanine + water ternary system under atmospheric pressure at temperatures of 278.15 K-318.15 K was explored <I>via</I> isothermal solution saturation. The isothermal equilibrium phase diagram of the ternary system was constructed. The obtained solid-liquid equilibrium data were correlated with a semi-empirical-model, yielding thermodynamic parameters <I>pa, pb, pc</I>, and <I>k</I>. Furthermore, the model can be used to effectively predict the solid-liquid equilibrium data of ternary systems at other temperatures, and the d<I>Y</I> and d<I>P</I> are 0.005 and 4.34%, respectively. The solid-liquid equilibrium data and ternary equilibrium phase diagrams of the system were utilized for the separation and purification of an <SMALL>L</SMALL>-tryptophan and <SMALL>L</SMALL>-phenylalanine mixture. By employing thermodynamic models to calculate the relevant phase diagram data for mixtures with different proportions, effective separation and purification of the mixture could be achieved using the principles of variable temperature phase diagrams. These works are valuable for optimizing chemical processes and have practical implications in the field.</P><P>Graphic Abstract</P><P>The phase diagram of solid-liquid equilibrium of amino acid aqueous solution in a ternary system is used in the separation and purification process.<BR/><IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=d3cp05690b'/><BR/></P>