BioChem - DOS

Blood-Catalyzed RAFT Polymerization

Angewandte Chemie

Reyhani, Amin; Nothling, Mitchell D.; Ranji‐ Burachaloo, Hadi; McKenzie, Thomas G.; Fu, Qiang; Tan, Shereen; Bryant, Gary; Qiao, Greg G.

<P><B>Abstract</B></P><P>The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition&#8208;fragmentation chain transfer (RAFT) process is reported for the first time. No pre&#8208;treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Owing to the naturally occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules.</P>

2018

0044-8249

1521-3757

130

32

pp.10445-10449

10.1002/ange.201802544

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART86679097

H&auml; moglobin; Polymerisationen; RAFT; Rote Blutk&ouml; rperchen;