BioChem - DOS

Highly Enantioselective Reduction of α-Methylated Nitroalkenes

Angewandte Chemie. international edition

Burda, Edyta; Reß , Tina; Winkler, Till; Giese, Carolin; Kostrov, Xenia; Huber, Tobias; Hummel, Werner; Grö ger, Harald

<P><B>Highly selective:</B> The reduction of &alpha;&#8208;methyl&#8208;substituted nitroalkenes succeeds in a highly enantioselective fashion with an ene reductase from <I>Gluconobacter oxydans.</I> Under optimized reaction conditions the desired nitroalkanes are formed with enantiomeric excesses of up to 95% in these biotransformations.</P>

2013

1433-7851

1521-3773

52

35

pp.9323-9326

10.1002/anie.201301814

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART69163427

asymmetric catalysis; biocatalysis; nitroalkanes; nitroalkenes; reduction