BioChem - DOS

Production of Hydroxy Acids: Selective Double Oxidation of Diols by Flavoprotein Alcohol Oxidase

Angewandte Chemie. international edition

Martin, Caterina; Trajkovic, Milos; Fraaije, Marco W.

<P><B>Abstract</B></P><P>Flavoprotein oxidases can catalyze oxidations of alcohols and amines by merely using molecular oxygen as the oxidant, making this class of enzymes appealing for biocatalysis. The FAD&#8208;containing (FAD=flavin adenine dinucleotide) alcohol oxidase from <I>P. chrysosporium</I> facilitated double and triple oxidations for a range of aliphatic diols. Interestingly, depending on the diol substrate, these reactions result in formation of either lactones or hydroxy acids. For example, diethylene glycol could be selectively and fully converted into 2&#8208;(2&#8208;hydroxyethoxy)acetic acid. Such a facile cofactor&#8208;independent biocatalytic route towards hydroxy acids opens up new avenues for the preparation of polyester building blocks.</P>

2020

cc-by-nc

1433-7851

1521-3773

59

12

pp.4869-4872

10.1002/anie.201914877

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART99298683

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.201914877

biocatalysis; diols; enzymes; lactones; oxidation