BioChem - DOS

Improved biooxidation of Benzyl alcohols catalyzed by the flavoprotein (5-Hydroxymethyl)furfural oxidase in organic solvents

Tetrahedron

Pickl, M.; Jost, E.; Glueck, S.M.; Faber, K.

The biooxidation of benzylic alcohols catalyzed by (5-hydroxymethyl)furfural oxidase (HMFO) to the corresponding benzaldehydes or benzoic acids was investigated in the presence of various organic (co)solvents. Whereas the enzyme activity decreased at elevated concentrations of water-miscible polar solvents, the presence of (halogenated) hydrocarbons was tolerated up to 90% (v/v), which led to drastically improved conversions of up to >99% in case of hexafluorobenzene. This remarkable effect was correlated with the improved solubility of O<SUB>2</SUB> in the employed solvents. Reaction rates were boosted by O<SUB>2</SUB>-saturation of solvents.

2017

Pergamon Press

0040-4020

1464-5416

73

36

pp.5408-5410

10.1016/j.tet.2017.07.038

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART78313868

Biocatalysis; HMF-oxidase; O2-oxidation; Organic solvent; Benzylic alcohol