BioChem - DOS

Different Strategies To Improve Lactic Acid Productivity Based on Microorganism Physiology and Optimum Operating Conditions

Industrial & engineering chemistry research

Alves de Oliveira, Regiane; Vaz Rossell, Carlos E.; Lunelli, Betâ nia H.; Schichi, Pedro O. M.; Venus, Joachim; Filho, Rubens Maciel

<P>Despite the broad variety of substrates tested for lactic acid production, most of them have problems, even those with promising results. The use of sugar cane molasses appears as a viable alternative, allowing the development of high-performance lactic acid production with yeast extract. In this study, different strategies are proposed and evaluated to achieve high yield, productivity, and lactic acid concentrations considering the suitable association among strain physiology, osmotic stress, substrates, pH control, and fermentation operational parameters. With these strategies and using molasses as a substrate, it was possible to obtain a yield of 95%, with a productivity of 5.38 g L<SUP>-1</SUP> h<SUP>-1</SUP>, and a titer of 157.95 g/L of lactic acid.</P><BR>[FIG OMISSION]</BR>

2018

American Chemical Society

0888-5885

1520-5045

57

31

pp.10118-10125

10.1021/acs.iecr.8b01655

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART94046906