Enabling Selective and Sustainable P450 Oxygenation Technology. Production of 4-Hydroxy-α-isophorone on Kilogram Scale

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논문

Enabling Selective and Sustainable P450 Oxygenation Technology. Production of 4-Hydroxy-α-isophorone on Kilogram Scale

학술지

Organic process research & development

저자명

Kaluzna, Iwona; Schmitges, Thomas; Straatman, Harrie; van Tegelen, Dennis; Mü ller, Monika; Schü rmann, Martin; Mink, Daniel

초록

The development of P450 platform technology has enabled the sustainable production of an oxygenated intermediate, 4-hydroxy-α-isophorone, on kilogram scale. Application of a cytochrome P450 enzyme resulted in an unprecedented product concentration of 10 g/L and a space–time yield of 1.5 g/L/h. These findings are highly relevant for the economical evaluation of cytochrome P450 technology and, additionally, provide access to an alternative and cost-effective route toward 4-hydroxy-α-isophorone.Graphic Abstract <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/2016/oprdfk.2016.20.issue-4/acs.oprd.5b00282/production/images/medium/op-2015-00282b_0008.gif'>

발행연도

2016

발행기관

American Chemical Society

ISSN

1083-6160

ISSN

1520-586x

권

호

페이지

pp.814-819