초록
<P><B>Abstract</B></P> <P>A novel electroactive macromonomer based on poly(<SMALL>L</SMALL>-lactic acid) (PLLA) with (3,4-ethylenedioxythiophene) (EDOT) functional end groups, was prepared by a traditional approach of organometallic polymerization with stannous octanoate [Sn(oct<SUB>2</SUB>)] and enzymatic polymerization using immobilized <I>Candida antarctica</I> Lipase B (CAL-B) and Amano lipase <I>Pseudomonas cepacia</I>(PS-IM), as catalysts. In the synthetic strategy, (2,3-dihydrothieno[3,4-b] dioxin-2-yl)methanol (EDOT-OH) was used to initiate the ring opening polymerization of lactide to yield PLLA with EDOT end group. All macromonomers (EDOT-PLLA) were characterized by <SUP>1</SUP>H and <SUP>13</SUP>C RMN, MALDI-TOF, GPC and EDX. Moreover, ICP-OES analysis showed the presence of Sn traces in the material synthesized by the traditional approach, but that pathway led to macromonomers with higher molecular weight while the enzymatic route led to completely metal-free macromonomers with medium and lower molecular weights. Also, electrochemical and chemical polymerization of EDOT-PLLA were tested showing that it is possible to prepare degradable conducting polymers based on poly(3,4-ethylenedioxythiphene) (PEDOT). The biocatalytic synthesis is a very promising and environmental friendly pathway for the preparation of biodegradable materials for short time applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> One step enzymatic pathway synthesis of degradable electroactive macromonomers. </LI> <LI> Enzymatic route leads to metal-free macromonomers. </LI> <LI> EDOT-PLLA macromonomers can be copolymerized with EDOT by oxidation. </LI> <LI> Degradable and conducting PEDOT copolymers suitable for biomedical applications. </LI> </UL> </P>