BioChem - DOS

Techno-economic analysis of processes for Aspergillus carbonarius polygalacturonase production

Journal of bioscience and bioengineering

Nakkeeran, Ekambaram; Gowthaman, Marichetti Kuppuswamy; Umesh-Kumar, Sukumaran; Subramanian, Rangaswamy

<P><B>Abstract</B></P><P>A techno-economic analysis of submerged (SmF) and solid state fermentation (SSF) processes for <I>Aspergillus carbonarius</I> polygalacturonase production was performed to make an appropriate process selection. The downstream processing involved integrated membrane process (IMP) and alginate affinity precipitation (AAP). For a production scale of 30kL purified polygalacturonase concentrate per year, the total upstream cost of SmF was 14% lower than the SSF process. Downstream processing cost by IMP was 47% lower than AAP. The SmF-IMP process required a total capital investment that was 15&ndash;24% lower than the SmF-AAP and SSF-AAP processes. The corresponding unitary product cost was also lower by 24&ndash;36% in SmF-IMP process. Thus the SmF-IMP process proved to be very attractive from an economic point of view.</P>

2012

Elsevier

1389-1723

1347-4421

113

5

pp.634-640

10.1016/j.jbiosc.2011.12.021

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART62250834

Economic analysis; Aspergillus carbonarius; Polygalacturonase; Submerged fermentation; Solid-state fermentation; Integrated membrane process; Alginate affinity precipitation