Artificial Multi-Enzyme Networks for the Asymmetric Amination of sec-Alcohols

BioChem - DOS

Search

메타 데이터

바이오화학분류

- 바이오플라스틱
  1. 기타
- 바이오정밀화학
  1. 기타
- 화장품용 기능성소재
  1. 기능성
  2. 기타
- 의료용 화학소재
  1. 건강보조식품
  2. 식품첨가제

논문

Artificial Multi-Enzyme Networks for the Asymmetric Amination of sec-Alcohols

학술지

Chemistry : a European journal

저자명

Tauber, Katharina; Fuchs, Michael; Sattler, Johann H.; Pitzer, Julia; Pressnitz, Desiree; Koszelewski, Dominik; Faber, Kurt; Pfeffer, Jan; Haas, Thomas; Kroutil, Wolfgang

초록

AbstractVarious artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec‐alcohols to the corresponding α‐chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary of a range of different sec‐alcohol substrates. Alcohols were oxidised to the corresponding ketone by an alcohol dehydrogenase. The ketones were subsequently aminated by employing a ω‐transaminase. Of special interest were redox‐neutral designs in which the hydride abstracted in the oxidation step was reused in the amination step of the cascade. Under optimised conditions up to 91 % conversion of an alcohol to the amine was achieved.

발행연도

2013

ISSN

0947-6539

ISSN

1521-3765

권

호

페이지

pp.4030-4035

DOI

10.1002/chem.201202666