BioChem - DOS

Nitrile biotransformation by whole cells of Aspergillus sp. PTCC 5266

Biocatalysis and biotransformation

Yousefi, M.; Mohammadi, M.; Habibi, Z.; Cheraghi, Z.

<P><I>Aspergillus</I> sp. PTCC 5266 exhibited nitrile-hydrating activity over a broad pH range from 6.0 to 10.0 at 26&deg;째C. It hydrated 4-nitrophenylacetonitrile, 2-chlorobenzonitrile and 3-chlorobenzonitrile to their corresponding carboxylic acids and amides, while benzyl cyanide, benzonitrile, 4-tolunitrile, cyclohexanecarbonitrile, 4-chlorobutyronitrile and isobutyronitrile gave carboxylic acids as the sole products. The maximum whole-cell nitrile-hydrating activity was observed at pH 7.0.</P>

2011

Informa Healthcare

1024-2422

1029-2446

29

2

pp.54-59

10.3109/10242422.2010.550002

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART56575339

Aamide; Aspergillus sp. PTCC 5266; carboxylic acid; nitrile biotransformation; nitrile hydrating activity