초록
<P><B>Abstract</B></P> <P>Succinic acid is a four-carbon dicarboxylic acid, which has attracted much interest due to its abroad usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of model strains, and process optimization for succinic acid production have been developed. This review provides an overview of succinic acid producers and cultivation technology, highlight some of the successful metabolic engineering approaches.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This review provides an overview of different producers for succinate production. </LI> <LI> Production of succinate from renewable resources is discussed in detail. </LI> <LI> This review shows some successful metabolic engineering approaches for succinate production. </LI> <LI> This review provides an overview of key fermentative factors on succinate production. </LI> <LI> This review provides a perspective on remaining challenges for succinate economical production. </LI> </UL> </P>