Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae

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  2. 식품첨가제

논문

Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae

학술지

ACS energy letters

저자명

Xu, Ke; Qin, Lei; Bai, Wenxin; Wang, Xiaoyan; Li, Fan; Ren, Shichao; Gao, Xiaopeng; Chen, Bo; Tong, Yi; Li, Jun; Li, Bing-Zhi; Yuan, Ying-Jin; Li, Chun

초록

In the biofuel industry, improving the tolerance of Saccharomyces cerevisiae to the multiple stresses is essential to enhance the production efficiency and reduce the economic cost. We herein developed a multilevel defense system (MDS) by random assembly of tolerance genetic circuits, adaptive evolution, and multistep screening to obtain industrial yeasts with higher robustness and productivity. MDS was applied to increase the ethanol concentration by 6.9% in industrial pilot-scale fermentation at high temperature, and the energy consumption for the cooling was decreased by 45.1% compared with that for the normal process. Furthermore, MDS showed a significant effect on relieving the multiple stresses by reducing intracellular reactive oxygen species (ROS) and balancing the productive transcriptional performance. This system offers a new solution for remolding industrial yeast and may accelerate further development of ethanol refinery. [FIG OMISSION]

발행연도

2020

발행기관

American Chemical Society

ISSN

2380-8195

권

페이지

pp.572-582

DOI

10.1021/acsenergylett.9b02681.s001

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