BioChem - DOS

Enzyme-PISA: An Efficient Method for Preparing Well-Defined Polymer Nano-Objects under Mild Conditions

Macromolecular rapid communications

Tan, Jianbo; Xu, Qin; Li, Xueliang; He, Jun; Zhang, Yuxuan; Dai, Xiaocong; Yu, Liangliang; Zeng, Ruiming; Zhang, Li

<P><B>Abstract</B></P><P>Enzyme catalysis is a mild, efficient, and selective technique that has many applications in organic synthesis as well as polymer synthesis. Here, a novel enzyme&#8208;catalysis&#8208;induced reversible addition&#8208;fragmentation chain transfer (RAFT)&#8208;mediated dispersion polymerization for preparing AB diblock copolymer nano&#8208;objects with complex morphologies at room temperature is described. Taking advantage of the room&#8208;temperature feature, it is shown that pure, worm&#8208;like polymer nano&#8208;objects can be readily prepared by just monitoring the viscosity. Moreover, it is demonstrated that inorganic nanoparticles and proteins can be loaded in situ into vesicles by this method. Finally, a novel oxygen&#8208;tolerant RAFT&#8208;mediated dispersion polymerization initiated by enzyme cascade reaction that can be carried out in open vessels is developed. The enzyme&#8208;initiated RAFT dispersion polymerization provides a facile platform for the synthesis of various functional polymer nano&#8208;objects under mild conditions.</P>

2018

1022-1336

1521-3927

39

9

pp.1700871

10.1002/marc.201700871

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART83618221

diblock copolymers; enzyme catalysis; oxygen&#x2010; tolerant; PISA;