초록
An unprecedented trithio-derivative of epidiketopiperazine, chlorotrithiobrevamide (1), was produced by the Palauan marine-derived fungus Trichoderma sp. TPU199 (cf. T. brevicompactum) in natural seawater medium supplemented with DMSO, together with the known chloro-epidithiodiketopiperazine, DC1149B (2). The structure of 1 was elucidated on the basis of its spectroscopic data and a comparison with that of 2. Compound 1 possessed a Cl atom and a trisulfide bridge between the α- and β-positions of two amino acid residues. The absolute configuration of 1 was deduced from a comparison of its Electronic Circular Dichroism (ECD) spectrum with those of related compounds.