Asymmetric Biocatalytic Amination of Ketones at the Expense of NH3 and Molecular Hydrogen

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논문

Asymmetric Biocatalytic Amination of Ketones at the Expense of NH3 and Molecular Hydrogen

학술지

Organic letters

저자명

Holzer, Anja K.; Hiebler, Katharina; Mutti, Francesco G.; Simon, Robert C.; Lauterbach, Lars; Lenz, Oliver; Kroutil, Wolfgang

초록

A biocatalytic system is presented for the stereoselective amination of ketones at the expense of NH3 and molecular hydrogen. By using a NAD+-reducing hydrogenase, an alanine dehydrogenase, and a suitable ω-transaminase, the R- as well as the S-enantiomer of various amines could be prepared with up to >99% ee and 98% conversion.Graphic Abstract <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2015/orlef7.2015.17.issue-10/acs.orglett.5b01154/production/images/medium/ol-2015-01154z_0004.gif'><A href='http://pubs.acs.org/doi/suppl/10.1021/ol5b01154'>ACS Electronic Supporting Info</A>

발행연도

2015

발행기관

American Chemical Society

ISSN

1523-7060

권

호

페이지

pp.2431-2433

DOI

10.1021/acs.orglett.5b01154