Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase

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논문

Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase

학술지

Organic process research & development

저자명

Modukuru, Naga K.; Sukumaran, Joly; Collier, Steven J.; Chan, Ann Shu; Gohel, Anupam; Huisman, Gjalt W.; Keledjian, Raquel; Narayanaswamy, Karthik; Novick, Scott J.; Palanivel, S. M.; Smith, Derek; Wei, Zhang; Wong, Brian; Yeo, Wan Lin; Entwistle, David A.

초록

This contribution describes the development of a ketoreductase enzyme over four rounds of directed evolution and the associated process development that enabled a practical, scalable process to (S)-licarbazepine (eslicarbazepine).Graphic Abstract <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/2014/oprdfk.2014.18.issue-6/op4003483/production/images/medium/op-2013-003483_0014.gif'><A href='http://pubs.acs.org/doi/suppl/10.1021/op4003483'>ACS Electronic Supporting Info</A>

발행연도

2014

발행기관

American Chemical Society

ISSN

1083-6160

ISSN

1520-586x

권

호

페이지

pp.810-815