Asymmetric synthesis of an enantiomerically pure rivastigmine intermediate using ketoreductase

BioChem - DOS

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논문

Asymmetric synthesis of an enantiomerically pure rivastigmine intermediate using ketoreductase

학술지

Tetrahedron, asymmetry

저자명

Sethi, M.K.; Bhandya, S.R.; Maddur, N.; Shukla, R.; Kumar, A.; Jayalakshmi Mittapalli, V.S.N.

초록

A novel chemo-enzymatic synthesis of (S)-rivastigmine using ketoreductases with NADH/NADPH as the proton donor has been demonstrated. An exclusive enzymatic process has been developed by exploring the possible ketoreductases by screening to identify enzymes useful for the preparation of the (S)-isomer intermediate, and scaling up of the enzymatic process for the production of an adequate, enantiomerically pure precursor of rivastigmine and for the total synthesis of (S)-rivastigmine.

발행연도

2013

발행기관

Pergamon

ISSN

0957-4166

ISSN

1362-511x

권

호

페이지

pp.374-379