초록
<P><B>Abstract</B></P> <P>It’s long been understood that antimicrobial properties are one of the most important function in the field of biomedicine. In this thesis, we introduce a new technique to functionalize bacterial cellulose (BC) with antimicrobial properties by <I>in situ</I> method. We design a series of experiments on hydrolyzing mulberry leaves and exploring the methods of fermenting and purifying to obtain a BC complex with antimicrobial properties. Meanwhile, the anti-bacterial performances of MH-BC (fermented by the mulberry leaves acid hydrolysate fermentation medium) were evaluated with <I>Escherichia coli</I> and <I>Staphylococcus aureus</I>, and the experimental results showed that the MH-BC have excellent anti-bacterial activities. Considering the excellent biocompatibility of MH-BC towards hMSCs, we expect that this antibacterial functional BC composite will find potential applications in biomedicine and regenerative medicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The discarded and cheap mulberry leaves was used to prepare bacterial cellulose. </LI> <LI> The as-prepared composite shows good antimicrobial properties and biocompatibility. </LI> <LI> The composite may be potential application in wound dressings. </LI> </UL> </P>