초록
<P>The development of an immobilized ketoreductase via covalent binding on resin EC-HFA has demonstrated that it is highly active and stable in organic solvents and can be recycled and reused many times in both batch mode and flow reactor mode. (<I>R</I>)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol, a key chiral intermediate in the synthesis of EMEND, was synthesized in 98% yield with >99% ee using the immobilized ketoreductase in a 50% hexanes/40% IPA/10% water solvent system. The immobilized ketoreductase has also been applied to the synthesis of various chiral alcohols.</P><P><B>Graphic Abstract</B><BR><IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/2015/oprdfk.2015.19.issue-7/op5003215/production/images/medium/op-2014-003215_0017.gif'></P>