BioChem - DOS

Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient

Bioresource technology : biomass, bioenergy, biowastes, conversion technologies, biotransformations, production technologies

Chang, G.; Gao, N.; Tian, G.; Wu, Q.; Chang, M.; Wang, X.

Volumetric mass transfer coefficient (k<SUB>L</SUB>a) is a key fermentation parameter for the production of docosahexaenoic acid (DHA) from glycerol by Schizochytrium sp. S31. In order to elucidate the effects of k<SUB>L</SUB>a on the fermentations, both baffled and unbaffled flask cultures and fed-batch cultures were developed in present work. The results showed that high k<SUB>L</SUB>a could effectively increase the DHA concentration, DHA productivity and conversion yield (Y<SUB>x/s,</SUB> g/g). When k<SUB>L</SUB>a was set at 1802+/-105h<SUP>-1</SUP> in the fed-batch culture, DHA concentration was achieved at 28.93g/L, DHA productivity at 301mg/L/h and Y<SUB>x/s</SUB> at 0.44+/-0.02g/g, all of which were significantly higher than those in the previous similar studies.

2013

Elsevier Applied Science

0960-8524

142

pp.400-406

10.1016/j.biortech.2013.04.107

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART66285317

DHA; Schizochytrium sp.; Oxygen; kLa; Glycerol