초록
<P><B>Abstract</B></P><P>The aim of this work was the development of a feed‐control for a succinic acid production fed‐batch process. The performed batch trials indicated a correlation between succinic acid production and base consumption pH control. Based on the metabolism of <I>Anaerobiospirillum succiniciproducens</I>, a theoretical correlation between base consumption and glucose feed was established and proved in cultivation trials. With the established fed‐batch process, the succinic acid yield could be increased to 0.875 (g/g glucose) in comparison to batch processes (0.60) with similar glucose concentrations. Additionally, the results indicate that the osmolarity of the medium has a significant influence on succinic acid production. Biotechnol. Bioeng. 2012; 109:1187–1192. © 2011 Wiley Periodicals, Inc.</P>