Stereodivergent Synthesis of 3-Hydroxyprolines and 3-Hydroxypipecolic Acids via Ketoreductase-Catalyzed Dynamic Kinetic Reduction

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논문

Stereodivergent Synthesis of 3-Hydroxyprolines and 3-Hydroxypipecolic Acids via Ketoreductase-Catalyzed Dynamic Kinetic Reduction

학술지

Advanced synthesis & catalysis

저자명

Prier, Christopher K.; Lo, Michael M.‐ C.; Li, Hongming; Yasuda, Nobuyoshi

초록

AbstractWe report a practical enzymatic approach for the stereoselective synthesis of hydroxylated cyclic amino acids. Using ketoreductases, cyclic ketoesters are converted with high diastereo‐ and enantioselectivity to all isomers of 3‐hydroxyproline and 3‐hydroxypipecolic acid via a dynamic kinetic reduction reaction. This work highlights the ability of enzymes to provide solutions to challenges in stereoselective synthesis.

발행연도

2019

ISSN

1615-4150

ISSN

1615-4169

권

361

호

페이지

pp.5140-5143

DOI