Productivity enhancement of C:C bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes

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논문

Productivity enhancement of C:C bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes

학술지

Chemical communications : Chem comm

저자명

Brenna, Elisabetta; Gatti, Francesco G.; Monti, Daniela; Parmeggiani, Fabio; Sacchetti, Alessandro

초록

To overcome the usually low productivities of the C&z.dbd;C bond bioreduction of α,β-unsaturated aldehydes we combined the in situ substrate feeding product removal (SFPR) technology with a cascade system comprising an isolated ene-reductase and a chemoselective alcohol dehydrogenase. Graphic AbstractThe combination of isolated enzymes with resin adsorption allowed a productivity increase of two orders of magnitude in the bioreduction of α-substituted unsaturated aldehydes. <img src='http://pubs.rsc.org/ej/CC/2011/c1cc16014a/c1cc16014a-ga.gif'>

발행연도

2012

발행기관

The Royal Society of Chemistry

ISSN

1359-7345

ISSN

1364-548x

권

호

페이지

pp.79-81