The First One-Pot Synthesis of L-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other L-7-Halotryptophans

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논문

The First One-Pot Synthesis of L-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other L-7-Halotryptophans

학술지

Organic letters

저자명

Smith, Duncan R. M.; Willemse, Tom; Gkotsi, Danai S.; Schepens, Wim; Maes, Bert U. W.; Ballet, Steven; Goss, Rebecca J. M.

초록

A simple and scalable one-pot biotransformation enables direct access to l-halotryptophans, including l-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required.Graphic Abstract <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2014/orlef7.2014.16.issue-10/ol5007746/production/images/medium/ol-2014-007746_0004.gif'><A href='http://pubs.acs.org/doi/suppl/10.1021/ol5007746'>ACS Electronic Supporting Info</A>

발행연도

2014

발행기관

American Chemical Society

ISSN

1523-7060

권

호

페이지

pp.2622-2625

DOI

10.1021/ol5007746