Production of itaconic acid by biotransformation of wheat bran hydrolysate with Aspergillus terreus CICC40205 mutant

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바이오화학분류

- 바이오플라스틱
  1. 고무
  2. 플라스틱
- 바이오정밀화학
  1. 화학제품
- 화장품용 기능성소재
  1. 계면활성제⁄증점제

논문

Production of itaconic acid by biotransformation of wheat bran hydrolysate with Aspergillus terreus CICC40205 mutant

학술지

Bioresource technology : biomass, bioenergy, biowastes, conversion technologies, biotransformations, production technologies

저자명

Wu, Xuefeng; Liu, Qing; Deng, Yongdong; Li, Jinghong; Chen, Xiaoju; Gu, Yongzhong; Lv, Xijun; Zheng, Zhi; Jiang, Shaotong; Li, Xingjiang

초록

Abstract The replacement of the carbon source in the microbial production of itaconic acid (IA) with economic alternatives has attracted significant attention. In this study, an Aspergillus terreus CICC40205 mutant was used to increase the IA titer and decrease the citric acid titer in the wheat bran hydrolysate compared with the parental strain. The results showed that the IA titer was increased by 33.4%, whereas the citric acid titer was decreased by 75.8%, and were in accordance with those of the improved pathway of co-metabolism of glucose and xylose according to the metabolic flux analysis. Additionally, the maximum IA titer obtained in a 7-L stirred tank was 49.65gL−1 ±0.38gL−1. Overall, A. terreus CICC40205 showed a great potential for the industrial production of IA through the biotransformation of the wheat bran hydrolysate. Highlights <UL> <LI> An Aspergillus terreus CICC40205 mutant using heat bran hydrolysate was got. </LI> <LI> Itaconic acid yield was increased and citric acid yield was decrease. </LI> <LI> Metabolic flux analysis of pathway from glucose and xylose using was studied. </LI> <LI> The maximum itaconic acid yield was 49.65gL−1 in a 7L stirred tank. </LI> </UL> Graphical abstract [DISPLAY OMISSION]

발행연도

2017

발행기관

Elsevier

ISSN

0960-8524

권

241

페이지

pp.25-34

DOI

10.1016/j.biortech.2017.05.080