BioChem - DOS

PREDICTORS OF 3-MONTH AND 1-YEAR VISUAL OUTCOMES AFTER VITRECTOMY WITH SUBRETINAL TISSUE PLASMINOGEN ACTIVATOR INJECTION FOR SUBMACULAR HEMORRHAGE

Retina

Miki, Makoto; Miyata, Manabu; Ooto, Sotaro; Tamura, Hiroshi; Ueda-Arakawa, Naoko; Muraoka, Yuki; Miyake, Masahiro; Hata, Masayuki; Takahashi, Ayako; Kido, Ai; Kogo, Takahiro; Uji, Akihito; Tsujikawa, Akitaka

<P>Purpose:<P>To investigate factors associated with 3-month or 1-year best-corrected visual acuity (BCVA) after vitrectomy with subretinal tissue plasminogen activator injection for submacular hemorrhage (SMH) and to identify the predictors of early displacement.</P></P><P>Methods:<P>This prospective cohort study included consecutive eyes with SMH complicating neovascular age-related macular degeneration or retinal macroaneurysm that underwent vitrectomy with subretinal tissue plasminogen activator injection and were followed up for at least 3 months. Parameters that correlated with 3-month BCVA, 1-year BCVA, and 2-week displacement grade (0-3) were identified.</P></P><P>Results:<P>Twenty-nine eyes of 29 patients (73.1 ± 8.4 years; neovascular age-related macular degeneration, 25 eyes) were included. Logarithm of the minimum angle of resolution BCVA improved 3 months after the surgery (baseline, 0.76 [20/115] ± 0.35; 3-month, 0.51 [20/65] ± 0.32; <I>P</I> = 0.006). In multivariable analyses, 1-year logarithm of the minimum angle of resolution BCVA correlated with age (<I>P</I> = 0.007, &beta; = 0.39) and SMH recurrence within 1 year after surgery (<I>P</I> < 0.001, &beta; = 0.65). Two-week displacement grade correlated with the contrast-to-noise ratio of SMH (<I>P</I> = 0.001, &beta; = &#x2212;0.54). Macular hole occurred in three eyes (10%) with small SMH size and was closed in all eyes via additional vitrectomy with an inverted internal limiting membrane flap technique.</P></P><P>Conclusion:<P>The recurrence of SMH negatively affected the 1-year visual outcome after vitrectomy with subretinal tissue plasminogen activator injection for SMH. The contrast-to-noise ratio was a useful predictor of early SMH displacement, but not of 1-year BCVA. Further research is necessary to determine the optimal treatment to prevent SMH recurrence.</P></P>

2023

Ovid Technologies (Wolters Kluwer) - Lippincott WilliamsWilkins

0275-004x

1539-2864

43

11

pp.1971-1979

10.1097/iae.0000000000003885

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART126664759