초록
<P><B>Abstract</B></P><P><B>BACKGROUND</B></P><P>Succinic acid is one of the most important biorefinery platform chemicals. The fibrous‐bed bioreactor (FBB), comprising spiral cotton fiber packed in a modified bioreactor, is effective for anaerobic cell‐immobilized fermentation. In this study, fermentation production of succinic acid by <I>Actinobacillus succinogenes</I> using a FBB was investigated.</P><P><B>RESULTS</B></P><P>The effect of different initial glucose concentrations on succinic acid production in batch fermentation in a FBB was examined, which indicated that the optimal initial glucose concentration was 55 g L<SUP>‐1</SUP>. In 10 batches of repeated‐batch fermentation, the average succinic acid productivity, concentration, and yield were 3.61 g L<SUP>‐1</SUP> h<SUP>‐1</SUP>, 39.0 g L<SUP>‐1</SUP>, and 0.85 g g<SUP>‐1</SUP>, respectively. A maximum succinic acid concentration of 98.7 g L<SUP>‐1</SUP> was reached in fed‐batch fermentation comprising four batches of fermentation, with a succinic acid yield of 0.89 g g<SUP>‐1</SUP> and productivity of 2.77 g L<SUP>‐1</SUP> h<SUP>‐1</SUP>.</P><P><B>CONCLUSION</B></P><P>Succinic acid fermentation by <I>A. succinogenes</I> in a FBB was successfully performed to enhance succinic acid productivity. And also, high succinic acid concentration with high reactor productivity and yield were simultaneously achieved in the FBB with fed‐batch fermentation. © 2013 Society of Chemical Industry</P>