BioChem - DOS

Biopolymer production in a fed-batch reactor using optimal feeding strategies

Journal of chemical technology and biotechnology

Lai, Song‐ Yi; Kuo, Po‐ Chih; Wu, Wei; Jang, Ming‐ Feng; Chou, Yi‐ Shyong

<P><B>Abstract</B></P><P><B>Background</B></P><P><B>Polyhydroxybutyrate (PHB), an important member of the family of polyhydroxyalkanoates (PHAs), is a biodegradable thermoplastic synthesized by numerous microorganisms under different cultivation conditions</B>.</P><P><B>Results</B></P><P><B>A simple dynamic model for producing PHB in a fed&#8208;batch reactor is presented. The kinetic model accuracy is quantified by the specific error measures. The dynamic manipulation scheme with prescribed stepwise changes is used to improve PHB productivity. A multi&#8208;objective optimization algorithm is used to determine the optimal feeding strategy</B>.</P><P><B>Conclusion</B></P><P><B>Reduced kinetic models in a mixed culture cultivation process for PHB production are successfully verified. An optimization&#8208;based feeding strategy with stepwise changes has been derived and successfully validated. &copy; 2013 Society of Chemical Industry</B></P>

2013

John Wiley Sons, Ltd

0268-2575

1097-4660

88

11

pp.2054-2061

10.1002/jctb.4067

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART67453690

biopolymers; kinetics; optimization; identification