Pilot-scale validation of Enzymatic Reactive Distillation for butyl butyrate production
메타 데이터
바이오화학분류
바이오플라스틱
플라스틱
바이오정밀화학
용매
화학제품
연료
화장품용 기능성소재
계면활성제⁄증점제
의료용 화학소재
식품첨가제
논문
Pilot-scale validation of Enzymatic Reactive Distillation for butyl butyrate production
학술지
Chemical engineering journal
저자명
Wierschem, Matthias; Schlimper, Stefan; Heils, Rene; Smirnova, Irina; Kiss, Anton A.; Skiborowski, Mirko; Lutze, Philip
초록
<P><B>Abstract</B></P> <P>For enzyme-catalyzed reactions, batch processes using stirred tank reactors are the state-of-the-art production mode. The yield of the process may be limited by reaction equilibrium, product inhibition of the enzyme, low concentrations and possibly low reaction rates, while the recovery of the product may be limited due to thermodynamic constraints such as azeotropes. Using enzymes in an integrated reactive distillation process can overcome these limitations and provides a cost advantage over classic batch reactor processes.</P> <P>The aim of this paper is i) to report the successful pilot-scale experimental validation of an Enzymatic Reactive Distillation (ERD) process for the synthesis of butyl butyrate and ii) to establish a rate-based model for conceptual process design which can be quickly adapted to other systems.</P> <P>The main novelty is the application of a continuous RD column with enzymes as a heterogeneous catalyst provided in two different types of catalytic packing: loosely filled immobilized enzyme beads in standard packings with catalyst pockets and gauze packings with catalytic coating.</P> <P>Experimental pilot-scale experiments show the feasibility of ERD and allow the comparison of the different packing types based on catalytic performance as well as stability. Furthermore, these experiments are used to validate a predictive rate-based model to describe ERD which can be used to check the sensitivity of process and design parameters as well as to provide a quick adaption to other systems for quick evaluation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Butyl butyrate synthesis by Enzymatic Reactive Distillation is possible. </LI> <LI> Established rate-based model to describe Enzymatic Reactive Distillation. </LI> <LI> First time validation for an Enzymatic Reactive Distillation process model. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>