초록
<P>A new method for the asymmetric chemo-enzymatic Baeyer–Villiger oxidation of prochiral 4-methylcyclohexanone to (<I>R</I>)-4-methylcaprolactone in the presence of (±)-4-methyloctanoic acid, <I>Candida Antarctica</I> lipase B and 30% aq. H<SUB>2</SUB>O<SUB>2</SUB> has been developed. A mechanism for the asymmetric induction based on kinetic resolution of racemic carboxylic acids is proposed.</P><BR><BR><P>Graphic Abstract</P><P>A new method for the asymmetric chemo-enzymatic Baeyer–Villiger oxidation of 4-methylcyclohexanone to enantioenriched lactone in the presence of (±)-4-methyloctanoic acid, <I>Candida Antarctica</I> lipase B and 30% aq. H<SUB>2</SUB>O<SUB>2</SUB> has been developed.<BR><IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5cc08519e'><BR></P>