A mutation of Aspergillus niger for hyper-production of citric acid from corn meal hydrolysate in a bioreactor

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논문

A mutation of Aspergillus niger for hyper-production of citric acid from corn meal hydrolysate in a bioreactor

학술지

Journal of Zhejiang University. Science B. Biomedicine & biotechnology

저자명

Hu, Wei; Liu, Jing; Chen, Ji-hong; Wang, Shu-yang; Lu, Dong; Wu, Qing-hua; Li, Wen-jian

초록

<P>The properties of the screened mutants for hyper-production of citric acid induced by carbon ((12)C(6+)) ion beams and X-ray irradiation were investigated in our current study. Among these mutants, mutant H4002 screened from (12)C(6+) ion irradiation had a higher yield of citric acid production than the parental strain in a 250-ml shaking flash. These expanded submerged experiments in a bioreactor were also carried out for mutant H4002. The results showed that (177.7-196.0) g/L citric acid was accumulated by H4002 through exploiting corn meal hydrolysate (containing initial 200.0-235.7 g/L sugar) with the productivity of (2.96-3.27) g/(L???h). This was especially true when the initial sugar concentration was 210 g/L, and the best economical citric acid production reached (187.5±0.7) g/L with a productivity of 3.13 g/(L???h). It was observed that mutant H4002 can utilize low-cost corn meal as a feedstock to efficiently produce citric acid. These results imply that the H4002 strain has the industrial production potentiality for citric acid and offers strong competition for the citric acid industry.</P>

발행연도

2014

발행기관

Zhejiang University Press

ISSN

1673-1581

ISSN

1862-1783

권

호

페이지

pp.1006-1010