Engineered Enterobacter aerogenes for efficient utilization of sugarcane molasses in 2,3-butanediol production

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논문

Engineered Enterobacter aerogenes for efficient utilization of sugarcane molasses in 2,3-butanediol production

학술지

Bioresource technology : biomass, bioenergy, biowastes, conversion technologies, biotransformations, production technologies

저자명

Jung, M.Y.; Park, B.S.; Lee, J.; Oh, M.K.

초록

Sugarcane molasses is considered to be a good carbon source for biorefinery due to its high sugar content and low price. Sucrose occupies more than half of the sugar in the molasses. Enterobacter aerogenes is a good host strain for 2,3-butanediol production, but its utilization of sucrose is not very efficient. To improve sucrose utilization in E. aerogenes, a sucrose regulator (ScrR) was disrupted from the genomic DNA. The deletion mutation increased the sucrose consumption rate significantly when sucrose or sugarcane molasses was used as a carbon source. The 2,3-butanediol production from sugarcane molasses by the mutant was enhanced by 60% in batch fermentation compared to that by the wild type strain. In fed-batch fermentation, 98.69g/L of 2,3-butanediol production was achieved at 36h.

발행연도

2013

발행기관

Elsevier Applied Science

ISSN

0960-8524

권

139

페이지

pp.21-27

DOI

10.1016/j.biortech.2013.04.003