BioChem - DOS

Development and Scale-up of a Biocatalytic Process To Form a Chiral Sulfoxide

Organic process research & development

Goundry, William R. F.; Adams, Bradley; Benson, Helen; Demeritt, Julie; McKown, Steven; Mulholland, Keith; Robertson, Amy; Siedlecki, Paul; Tomlin, Paula; Vare, Kevin

<P>A Baeyer&ndash;Villiger monooxygenase enzyme has been used to manufacture a chiral sulfoxide drug intermediate on a kilogram scale. This paper describes the evolution of the biocatalytic manufacturing process from the initial enzyme screen, development of a kilo lab process, to further optimization for plant scale manufacture. Efficient gas&ndash;liquid mass transfer of oxygen is key to obtaining a high yield.</P><P><B>Graphic Abstract</B><BR><IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/2017/oprdfk.2017.21.issue-1/acs.oprd.6b00391/production/images/medium/op-2016-003917_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/op6b00391'>ACS Electronic Supporting Info</A></P>

2017

American Chemical Society

1083-6160

1520-586x

21

1

pp.107-113

10.1021/acs.oprd.6b00391.s001

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART77247581

https://doi.org/10.1021/acs.oprd.6b00391.s001