Deracemization of unnatural amino acid: homoalanine using D-amino acid oxidase and ω-transaminase

BioChem - DOS

Search

메타 데이터

바이오화학분류

- 바이오정밀화학
  1. 용매
  2. 화학제품
- 화장품용 기능성소재
  1. 계면활성제⁄증점제
- 의료용 화학소재
  1. 치료제
  2. 식품첨가제

논문

Deracemization of unnatural amino acid: homoalanine using D-amino acid oxidase and ω-transaminase

학술지

Organic & biomolecular chemistry

저자명

Seo, Young-Man; Mathew, Sam; Bea, Han-Seop; Khang, Yong-Ho; Lee, Sang-Hyeup; Kim, Byung-Gee; Yun, Hyungdon

초록

A deracemization method was developed to generate optically pure L-homoalanine from racemic homoalanine using D-amino acid oxidase and ω-transaminase. A whole cell reaction using a biphasic system converted 500 mM racemic homoalanine to 485 mM L-homoalanine (>99% ee). Graphic AbstractA deracemization method was developed to generate optically pure L-homoalanine from racemic homoalanine using D-amino acid oxidase and ω-transaminase. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2ob07161d'>

발행연도

2012

발행기관

The Royal Society of Chemistry

ISSN

1477-0520

ISSN

1477-0539

권

호

페이지

pp.2482-2485