Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign

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  1. 기능성

논문

Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign

학술지

Organic letters

저자명

Tailhades, Julien; Zhao, Yongwei; Schoppet, Melanie; Greule, Anja; Goode, Robert J. A.; Schittenhelm, Ralf B.; De Voss, James J.; Cryle, Max J.

초록

<P>Natural products are the greatest source of antimicrobial agents, although their structural complexity often renders synthetic production and diversification of key classes impractical. One pertinent example is the glycopeptide antibiotics (GPAs), which are highly challenging to synthesize due to their heavily cross-linked structures. Here, we report an optimized method that generates >75% tricyclic peptides from synthetic precursors in order to explore the acceptance of novel GPA precursor peptides by these key existent biosynthetic enzymes.</P><BR>[FIG OMISSION]</BR>

발행연도

2019

발행기관

American Chemical Society

라이선스

cc-by-nc

ISSN

1523-7060

권

호

페이지

pp.8635-8640