BioChem - DOS

Asymmetric reduction of ketones with recombinant E. coli whole cells in neat substrates

Chemical communications : Chem comm

Jakoblinnert, Andre; Mladenov, Radoslav; Paul, Albert; Sibilla, Fabrizio; Schwaneberg, Ulrich; Ansorge-Schumacher, Marion B.; de Marí a, Pablo Domí nguez

<P>The asymmetric reduction of ketones is performed by using lyophilized whole cells in neat substrates with defined water activity (<I>a</I><SUB>w</SUB>). Ketones and alcohols prone to be unstable in aqueous media can now be converted <I>via</I> biocatalysis.</P> <P>Graphic Abstract</P><P>Lyophilized <I>E. coli</I> whole-cells overexpressing carbonyl reductase catalyze the asymmetric reduction of ketones under water-free conditions, with high productivities and enantioselectivities.<BR><IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc14097c'><BR></P>

2011

Royal Society of Chemistry

1359-7345

1364-548x

47

44

pp.12230-12232

10.1039/c1cc14097c

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART57918820