Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

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논문

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

학술지

Green chemistry : an international journal and green chemistry resource : GC

저자명

Galman, James L.; Slabu, Iustina; Weise, Nicholas J.; Iglesias, Cesar; Parmeggiani, Fabio; Lloyd, Richard C.; Turner, Nicholas J.

초록

The discovery and characterisation of enzymes with both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals.Graphic AbstractBifunctional transaminases enable a strategy for the production of chiral amines using small excesses of diamine donors. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c6gc02102f'/>

발행연도

2017

발행기관

The Royal Society of Chemistry

ISSN

1463-9262

ISSN

1463-9270

권

호

페이지

pp.361-366